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Hudson product information:

Hudson Cata#: HB0044

Product Name: CO-101 (CP-4126)

CAS#: 22560-50-5 (clodronate disodium ), 10596-23-3 (clodronic acid)

Chemical Formula: CH4Cl2O6P2

Exact Mass: 243.88602

Molecular Weight: 244.89

Purity: 99%

Storage Info: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Synonym: clodronic acid disodium salt; disodium dichloromethylene diphosphonate; Dichloromethylenediphosphonic acid disodium salt. Foreign brand names: Bonefos; Clasteon; Difosfonal; Loron; Mebonat; Ossiten. Code name: CL2MDP; DMDP.


Structure Formula:

Structure Formula Not Available.

1g / $150.00
2 g / $260.00

Product Info::


If you want to make an order, please contact 1 (732) 640-2533

or email wzhuang@hudsonbiopharma.com


References (Review papers):

1: Poplin E, Wasan H, Rolfe L, Raponi M, Ikdahl T, Bondarenko I, Davidenko I, Bondar V, Garin A, Boeck S, Ormanns S, Heinemann V, Bassi C, Evans TR, Andersson R, Hahn H, Picozzi V, Dicker A, Mann E, Voong C, Kaur P, Isaacson J, Allen A. Randomized, Multicenter, Phase II Study of CO-101 Versus Gemcitabine in Patients With Metastatic Pancreatic Ductal Adenocarcinoma: Including a Prospective Evaluation of the Role of hENT1 in Gemcitabine or CO-101 Sensitivity. J Clin Oncol. 2013 Dec 10;31(35):4453-61. doi: 10.1200/JCO.2013.51.0826. Epub 2013 Nov 12. PubMed PMID: 24220555.

2: Stuurman FE, Lolkema MP, Huitema AD, Soetekouw PM, Rosing H, Rolfe L, Kaur P, Beijnen JH, van Tinteren H, Voest EE, Schellens JH. A phase 1 comparative pharmacokinetic and cardiac safety study of two intravenous formulations of CO-101 in patients with advanced solid tumors. J Clin Pharmacol. 2013 Aug;53(8):878-83. doi: 10.1002/jcph.108. Epub 2013 Jun 18. PubMed PMID: 23775853.