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Hudson product information:

Hudson Cata#: HB0042

Product Name: Clodronate

CAS#: 199807-35-7 (as monotrifluoroacetate).;

Chemical Formula: N/A

Exact Mass: N/A

Molecular Weight: N/A

Purity: N/A

Storage Info: N/A

Synonym: N/A


Structure Formula:

Structure Formula Not Available.


Product Info::

Clodronic acid (INN) or clodronate disodium (USAN) is a bisphosphonate. It is used in experimental medicine to selectively deplete for macrophages. It is also approved for human use in Canada, the United Kingdom and Italy, where it is marketed as Bonefos, Loron and Clodron and prescribed as a bone resorption inhibitor and antihypercalcemic agent. (source: http://en.wikipedia.org/wiki/Clodronic_acid).

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References (Review papers):

1: Muratore M, Quarta E, Grimaldi A, Calcagnile F, Quarta L. Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates. Drug Des Devel Ther. 2011;5:445-54. doi: 10.2147/DDDT.S12139. Epub 2011 Oct 19. Review. PubMed PMID: 22087064; PubMed Central PMCID: PMC3210073.

2: Crépin S, Laroche ML, Sarry B, Merle L. Osteonecrosis of the jaw induced by clodronate, an alkylbiphosphonate: case report and literature review. Eur J Clin Pharmacol. 2010 Jun;66(6):547-54. doi: 10.1007/s00228-010-0822-5. Epub 2010 May 1. Review. PubMed PMID: 20437036.