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Hudson product information:

Hudson Cata#: HB0041

Product Name: Clodronate

CAS#: 88968-51-6 (free base);

Chemical Formula: C27H40N8O7

Exact Mass: 588.302

Molecular Weight: 588.66

Purity: N/A

Storage Info: N/A

Synonym: EMD 121974;EMD-85189;EMD-121974;NSC-707544;D03497;Cyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl)


Structure Formula:

Structure Formula Not Available.


Product Info::

Cilengitide is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels). Hence, it is under investigation for the treatment of glioblastoma by inhibiting angiogenesis. The European Medicines Agency has granted cilengitide orphan drug status.

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References (Review papers):

1: Scaringi C, Minniti G, Caporello P, Enrici RM. Integrin inhibitor cilengitide for the treatment of glioblastoma: a brief overview of current clinical results. Anticancer Res. 2012 Oct;32(10):4213-23. Review. PubMed PMID: 23060541.

2: Kurozumi K, Ichikawa T, Onishi M, Fujii K, Date I. Cilengitide treatment for malignant glioma: current status and future direction. Neurol Med Chir (Tokyo). 2012;52(8):539-47. Review. PubMed PMID: 22976135.