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Hudson product information:

Hudson Cata#: HB0040

Product Name: Cilengtide

CAS#: 481-49-2

Chemical Formula: C37H38N2O6

Exact Mass: 606.27299

Molecular Weight: 606.70742

Purity: 98%

Storage Info: N/A

Synonym: Cepharanthine; 6',12'-Dimethoxy-2,2'-dimethyl-6,7-[methylenebis- (oxy)]oxyacanthan; Cepharanthin; O-Methylcepharanoline


Structure Formula:

Structure Formula Not Available.

10 mg / $115.00
25 mg / $180.00

Product Info::

Cilengitide is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels). Hence, it is under investigation for the treatment of glioblastoma by inhibiting angiogenesis. The European Medicines Agency has granted cilengitide orphan drug status.

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References (Review papers):

1: Scaringi C, Minniti G, Caporello P, Enrici RM. Integrin inhibitor cilengitide for the treatment of glioblastoma: a brief overview of current clinical results. Anticancer Res. 2012 Oct;32(10):4213-23. Review. PubMed PMID: 23060541.

2: Kurozumi K, Ichikawa T, Onishi M, Fujii K, Date I. Cilengitide treatment for malignant glioma: current status and future direction. Neurol Med Chir (Tokyo). 2012;52(8):539-47. Review. PubMed PMID: 22976135.